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SLE Pathology and the Role of the Female Hormone Estrogen

SLE Pathology and the Role of the Female Hormone Estrogen

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SLE Pathology and the Role of the Female Hormone Estrogen Spotlighted

... 4. CAUSES CONTINUE… 3) Sex and hormones SLE affects women ...

HORMONAL FACTORS CAUSING SLE
Estrogen and other female ...

ROLE OF HORMONES IN HUMAN SLE ...

Increased levels of metabolites with 16-alphahydroxylation have been found in studies of estrogen metabolites of both males and females with SLE.

Factors contributing to the pathogenesis of SLE

In systemic lupus erythematosus (SLE), many geneti

PATHOPHYSIOLOGY OF SLE ...

7 Hormonal factors: Estrogen ...

6. Genetic s Hormones ...

SLE Pathology and the Role of the Female Hormone Estrogen Spotlighted | Autoimmune disease, Autoimmune and Immune system

... Causes of SLE The exact cause of SLE isn't known, but several factors ...

Stepwise approach in the treatment of SLE. NSAID, Nonsteroidal antiinflammatory drugs; IVIg,

In systemic lupus erythematosus (SLE), many geneti

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SYSTEMIC LUPUS ERYTHEMATOSUS (LUPUS) CAUSES | SYMPTOMS | DIAGNOSIS | TREATMENTS ...

The role of hormones in the sexual dimorphism in autoimmunity. The strong gender bias in autoimmune disease susceptibility could be due to the differential ...

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Importance of Sex hormones  Female ...

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... response; 18.

Treatment Approaches for SLE.

PATHOPHYSIOLOGY ...

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Pathogenic Autoantibodies in Systemic Lupus Erythematosus.

2. 2 SYSTEMIC LUPUS ERYTHEMATOSUS ...

Overview of the Pathogenesis of Systemic Lupus Erythematosus.

9 ETIOLOGY ...

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Targeted Therapeutic Approaches in Systemic Lupus Erythematosus.

Systemic Lupus Erythematosus Pathophysiology | Systemic Lupus Erythematosus | Immune System

SLE Patients with History of Psychosis, Neuropathy May Be at Risk of Seizures

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Systemic Lupus Erythematosus (SLE) Mukashev Slambek ...

Genetics and SLE

Renal pathology of male and female NZB/WF1 mice. Renal sections from 23-

6. Environment

Lupus Seen to Be Triggered in Mice by Leptin, a Hormone Often Elevated in…

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Schematic representation of the potential interplay of different types of .

New findings link estrogen and T cell immune response to autoimmune inflammation

Young woman with the typical "butterfly rash" found in lupus

Figure 79-1 Contributors to systemic lupus erythematosus (SLE) pathogenesis. Mechanisms that promote development of SLE are related to the underlying ...

SLE Pathology and the Role of the Female Hormone Estrogen Spotlighted | Autoimmune disease, Autoimmune and Immune system

Etiology: Unknown Multifactorial: Genetic Hormonal Immunologic and

Pictures of Systemic Lupus Erythematosus

Chromosome Loci and Genes Associated with SLE.

Table 1 Sex and age distribution of the studied groups

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... Hi-Res ...

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Researchers Study Interplay Between Vitamin D, INF-gamma and Estradiol in SLE

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Considering the role of environmental factors in SLE pathogenesis

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The multifaceted nature of systemic lupus erythematosus (SLE) is shown by the number of different organ systems that can be affected.

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Lupus Activity Index in Pregnancy.

Selected Baseline Demographic Features and Disease Characteristics of the 162 Women, According to the Assigned Method of Contraception.

Features of Lupus Nephritis on Immunofluorescence Staining and Transmission Electron Microscopy.

Neostell SAS partnership

Fig. 1

Systemic lupus erythematosus, commonly known as lupus, is an autoimmune disease that results in tissue damage and inflammation all over the body.

>Pathogenesis of SLE Environmental factors Ultraviolet light (flares in 70%) Increased apoptosis

Mean Activity of Systemic Lupus Erythematosus during 12 Months in 162 Women Using Combined Oral Contraceptives, a Progestin-Only Pill, or a Copper IUD.

Table 3. Mean Change in the SELENA-SLEDAI Instrument Score from Baseline, According to Treatment Group and Month of Follow-up.

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Metabolism of estradiol.

graphic

Deregulated mRNAs in female and male patients with SLE. (A

ERα binds to putative response sites in the ZAS3 locus and is essential for estrogen-mediated ZAS3 induction. (A) Four radio-labeled probes to estrogen ...

Figure 1 ...

ZAS3 expression is increased in SLE patients. (A) PBMCs from SLE patients were isolated and cultured with or without E2 (10 nM) for 48 h.

Pathogenesis in normal and SLE pregnancy.

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Figure 1 Risk factors of osteoporosis in systemic lupus erythematosus. SLE: Systemic lupus erythematosus; IL-6: Interleukin-6; TNF: Tumor necrosis factor; ...

Estrogen induces ZAS3 expression in mouse lymphoid tissue. Mice (n = 10) were injected subcutaneously with PBS or E2 (0.5 μg) daily and tissue was harvested ...

The follicular phase starts at the beginning of menstruation. Follicle stimulating hormone (FSH) starts to rise (produced ...

Clearance deficiency

Estrogen induction of ZAS3 expression in human hematopoietic and breast cancer cell lines. Indicated cells were incubated with β-estradiol (E2, ...

ANRF funded research on the pathology and causes of lupus is revealing new approaches towards developing therapies and a cure.

... Classification system for lupus nephritis according to ISN/RPS (2003) · Clinical-pathological correlations ...

Germinal centres

ZAS3 expression is up-regulated with estrogen stimulation in primary human PBMCs. Healthy PBMCs treated with E2 (10 nM) were compared to media controls.

Disease Activity among the 162 Treated Women and the Subgroup of 134 Women Who Had Active Disease at Baseline.

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Assessment of Lupus Flares in Pregnancy.

Dose-dependent and temporal expression of ZAS3 induced by estrogen in mouse mammary tumor cells. PYMT cells were treated with 10 nM E2 and harvested after ...

Differentiation of Microangiopathies in Lupus Pregnancy.

Figure 1. Schematic presentation of the proposed pathways linking environmental factors to the development of

Photosensitive systemic lupus erythematosus (SLE)

Table 4: Dermatosis aggravated by estrogen therapy

Estrogen stimulates STAT1 expression in primary human cells and is upregulated in

Figure 1: Renal histopathology slides - Findings correspond to lupus nephritis Class IV(S) A/C. (ISN/RPS 2004)* (a) Low-power view showing three glomeruli ...

Modulation of autoimmune rheumatic diseases by oestrogen and progesterone | Nature Reviews Rheumatology